Structure and Dynamic Regulation of Abl Kinases*
نویسندگان
چکیده
منابع مشابه
Structure and dynamic regulation of Abl kinases.
The c-abl proto-oncogene encodes a unique protein-tyrosine kinase (Abl) distinct from c-Src, c-Fes, and other cytoplasmic tyrosine kinases. In normal cells, Abl plays prominent roles in cellular responses to genotoxic stress as well as in the regulation of the actin cytoskeleton. Abl is also well known in the context of Bcr-Abl, the oncogenic fusion protein characteristic of chronic myelogenous...
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Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of chromosomal aberrations in different cancers. This causes the expression of Abl fusion proteins, such as Bcr-Abl, that are constitutively activated and drivers of tumorigenesis. Over the past decades, biochemical and functional studies on the molecular mechanisms of Abl regulation have gone hand in hand wit...
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The kinase activity of c-Abl is known to be tightly regulated. Mechanisms of c-Abl kinase regulation can be classified as intramolecular or intermolecular interactions. Crystallization of the amino (N)-terminal region of c-Abl has revealed that intramolecular folding of the N terminus onto the kinase domain represses intrinsic kinase activity. With regard to intermolecular interactions, recent ...
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15 صفحه اولMultifunctional Abl kinases in health and disease.
The Abelson tyrosine kinases were initially identified as drivers of leukemia in mice and humans. The Abl family kinases Abl1 and Abl2 regulate diverse cellular processes during development and normal homeostasis, and their functions are subverted during inflammation, cancer and other pathologies. Abl kinases can be activated by multiple stimuli leading to cytoskeletal reorganization required f...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.r112.438382